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Biodegradable Composite Bone Graft
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Fabrication and Characterization of 3D printed personalized biodegradable composite bone graft

Breif

The most important function of the bone is to provide a structural support to the body. In order for the successful reconstruction, the regenerative bone graft should have identical mechanical strength and structure to that of the natural bone to minimize the mismatch and stress shielding, ability to adhere and blend with the surrounding tissues, and elasticity to allow deformation during surgical insertion. However, currently available metallic, ceramic, biopolymeric, and decellularized matrix-based grafts are limited, as they are susceptible to immune response and plastic deformation, which may result in secondary tissue damages and losses. While the bone reconstruction surgery most commonly involves partial replacement and reconstruction of the bone, currently available grafts and treatments pose difficulties in deforming and fitting the implant or graft into the defect area. Therefore, the development of 3D printed personalized biodegradable composite bone graft can perfectly match with the demand of the surgeons in the field of personalized medicine and regenerative medicine.


Fig. 1. Schematic representation of 3D printed personalized bone graft fabrication process



Last CGI Updated: January 26, 2011
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